Amikacin Injection IP

Product Description

🉠Amikacin Injection IP

Amikacin is a broad-spectrum aminoglycoside antibiotic used to treat serious bacterial infections, especially those caused by gram-negative bacteria, including strains resistant to other antibiotics.

🔠Composition:

• Each mL typically contains:

  • Amikacin Sulfate equivalent to 250 mg or 500 mg of Amikacin

• Available in 2 mL or 2.5 mL ampoules or vials (e.g., 500 mg/2 mL).

… Indications:

Used to treat severe bacterial infections, including:

• Sepsis

• Urinary tract infections (UTIs)

• Lower respiratory tract infections (pneumonia)

• Intra-abdominal infections

• Skin and soft tissue infections

• Post-surgical infections

• Bone and joint infections

• Tuberculosis (as a second-line drug)

🉠Dosage & Administration:

šï Must be prescribed and dosed by a healthcare provider.

ž Adults:

• Usual dose: 15 mg/kg/day

• Given as once-daily or divided every 12 hours (e.g., 7.5 mg/kg q12h)

• Route: Intramuscular (IM) or Intravenous (IV) injection or infusion

ž Children:

• Typically: 15“20 mg/kg/day, divided into 2 or 3 doses

ž Neonates:

• Lower doses and extended intervals due to immature renal function

🔁 Duration:

• Usually 7“10 days depending on infection severity and clinical response

šï Monitoring:

• Monitor serum creatinine, urine output, and sometimes amikacin levels (peak and trough) to avoid toxicity

šï Precautions & Warnings:

• Nephrotoxicity: Risk of kidney damage “ monitor renal function closely

• Ototoxicity: Can cause hearing loss or balance issues (especially in long-term or high doses)

• Neuromuscular blockade: Caution in patients with myasthenia gravis or concurrent neuromuscular blockers

Contraindicated in:

• Known hypersensitivity to aminoglycosides

• Caution in patients with renal impairment

🪠Side Effects:

• Common:

  • Pain at injection site

  • Nausea, rash

• Serious:

  • Kidney damage

  • Hearing loss (can be permanent)

  • Dizziness, tinnitus (early signs of ototoxicity)

🊠Storage:

• Store below 25C

• Do not freeze

• Protect from light

• Use immediately after opening (multi-dose vials may require preservatives)