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Levofloxacin Tablets IP 500 mg is a broad-spectrum antibacterial agent belonging to the fluoroquinolone class. It is the L-isomer (active enantiomer) of ofloxacin and exhibits enhanced antibacterial activity. Levofloxacin is effective against a wide range of gram-positive and gram-negative bacteria.
Levofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This leads to the inhibition of bacterial cell division and ultimately results in bacterial cell death.
Each film-coated tablet contains:
Levofloxacin IP ï 500 mg
Pharmacokinetics:
Levofloxacin is rapidly and completely absorbed after oral administration, with a bioavailability of nearly 100%. Peak plasma concentrations are typically reached within 1 to 2 hours. It is widely distributed in body tissues and fluids and is primarily excreted unchanged in the urine.
Indications include:
Respiratory tract infections (e.g., pneumonia, bronchitis)
Urinary tract infections (UTIs)
Skin and soft tissue infections
Sinusitis
Prostatitis
Gastrointestinal infections (e.g., infectious diarrhea)
Certain cases of tuberculosis and multi-drug-resistant infections (as per physician guidance)
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