Clarithromycin Tablets IP 500MG

Product Description

Clarithromycin Tablets 500 mg is a macrolide antibiotic used to treat a wide range of bacterial infections. It is a semi-synthetic derivative of erythromycin and is effective against various gram-positive, gram-negative, and atypical pathogens.

Clarithromycin exerts its antibacterial effect by binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis. This action is primarily bacteriostatic, but it may be bactericidal at higher concentrations or against highly susceptible organisms.

Each film-coated tablet contains:

• Clarithromycin IP ï 500 mg

Pharmacokinetics:

Clarithromycin is well absorbed after oral administration, with a bioavailability of about 50%, which increases with food. It is extensively distributed throughout body tissues and fluids and is metabolized in the liver to its active metabolite, 14-hydroxy clarithromycin, which also possesses antimicrobial activity. Peak plasma levels are reached within 2 to 3 hours.

Indications:

• Community-acquired pneumonia (CAP)

• Acute bacterial exacerbation of chronic bronchitis

• Sinusitis and pharyngitis

• Skin and soft tissue infections

• Otitis media

• Helicobacter pylori eradication (in combination therapy for peptic ulcer disease)

• Mycobacterial infections (including disseminated Mycobacterium avium complex)

• Dental and orodental infections (as advised by a physician)

Advantages:

• Broad-spectrum activity

• Suitable for once or twice daily dosing

• Active against atypical pathogens (Mycoplasma, Chlamydia, Legionella)

• Well-tolerated with a favorable safety profile

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