Rabeprazole Gastrol Resistand and Domeperidone Prolonged Release Capsules

Ingredient	Formulation Type	Typical Strength	Function
Rabeprazole Sodium	Gastro-resistant (EC)	20 mg	Reduces stomach acid
Domperidone	Prolonged-release (SR)	30 mg	Enhances gut motility, anti-nausea effect

EC = Enteric-Coated
SR = Sustained Release

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Uses / Indications:

• Gastroesophageal reflux disease (GERD)

• Functional dyspepsia

• Acid reflux / heartburn

• Gastritis

• Nausea and bloating related to delayed gastric emptying

• Non-ulcer dyspepsia

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Dosage & Administration:

Usual Adult Dose
1 capsule once daily
Best taken 30 minutes before breakfast

Swallow whole with water do not chew or crush
Take at the same time each day for best results

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Precautions:

• Use with caution in:

  • Patients with cardiac arrhythmias or QT prolongation

  • Those on antifungals, macrolide antibiotics, or SSRIs (possible drug interactions)

• Long-term PPI use may lead to:

  • Vitamin B12 deficiency

  • Hypomagnesemia

  • Increased fracture risk

• Not recommended in:

  • Moderate to severe hepatic impairment (Domperidone)

  • Children under 12 years (unless specified by a doctor)

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Possible Side Effects:

Common	Less Common / Serious
Headache, abdominal pain	QT interval prolongation (Domperidone)
Nausea, dry mouth	Hypomagnesemia (Rabeprazole)
Diarrhea or constipation	Skin rash, allergic reaction
Fatigue or dizziness	Galactorrhea, gynecomastia (rare)

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Drug Interactions:

• Domperidone:

  • Avoid with ketoconazole, erythromycin, fluconazole increases QT risk

  • QT-prolonging drugs should be avoided

• Rabeprazole:

  • May reduce absorption of iron, calcium, Vitamin B12, and certain antifungals (e.g., itraconazole)

  • Caution with warfarin, digoxin, and clopidogrel

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Storage:

• Store at room temperature (1525C)

• Protect from heat, moisture, and direct sunlight

• Keep out of reach of children

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