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A combination therapy used to treat acid reflux, GERD, and functional dyspepsia. It combines:
Rabeprazole a proton pump inhibitor (PPI) that reduces stomach acid production
Itopride a prokinetic agent that improves gastric motility and accelerates stomach emptying
Together, they offer symptom relief in acid-related and motility-related gastrointestinal disorders.
Ingredient | Strength | Function |
---|---|---|
Rabeprazole Sodium (enteric-coated) | 20 mg | Suppresses gastric acid secretion (PPI) |
Itopride Hydrochloride (sustained release) | 150 mg | Increases gut motility; anti-nausea effects |
Formulation may be labeled as Rabeprazole EC + Itopride SR Capsules
Gastroesophageal reflux disease (GERD)
Non-ulcer dyspepsia (functional dyspepsia)
Heartburn, bloating, early satiety
Peptic ulcer disease
Gastroparesis (delayed gastric emptying)
Post-meal nausea or fullness
Typical Adult Dose | 1 capsule once daily, before breakfast |
---|---|
Duration | Usually 48 weeks or as prescribed |
Administration Notes | Swallow whole; do not chew or crush |
For best results, take 3060 minutes before food
Use with caution in:
Liver dysfunction
Electrolyte imbalances (may increase QT risk with Itopride)
Gastric malignancy rule out before starting long-term acid suppression
Elderly due to altered drug metabolism
Long-term PPI use may reduce calcium, magnesium, B12 levels
Common | Less Common / Serious |
---|---|
Headache, abdominal pain, flatulence | QT prolongation (rare, Itopride-related) |
Diarrhea or constipation | Vitamin B12 deficiency (with long-term use) |
Nausea, dizziness | Hypomagnesemia (with prolonged PPI use) |
Dry mouth or altered taste | Rash, hypersensitivity (rare) |
Antacids: Avoid taking togethermay affect Rabeprazole release
Warfarin, Digoxin, Phenytoin use cautiously
Ketoconazole, itraconazole absorption reduced by Rabeprazole
Levodopa, dopaminergic drugs antagonized by Itopride
Store in a cool, dry place below 25C
Protect from moisture and direct sunlight
Keep out of reach of children
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