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Prednisolone is a synthetic corticosteroid (glucocorticoid) with anti-inflammatory, immunosuppressive, and anti-allergic properties. It is commonly used to treat a wide range of autoimmune, inflammatory, and allergic conditions.
| Ingredient | Strength | Function |
|---|---|---|
| Prednisolone IP | 5 mg | Reduces inflammation and suppresses immune response |
Autoimmune disorders: Lupus, rheumatoid arthritis, autoimmune hepatitis
Allergic conditions: Severe asthma, urticaria, anaphylaxis (as adjunct)
Respiratory diseases: COPD exacerbations, bronchial asthma
Skin diseases: Eczema, psoriasis, contact dermatitis
Ocular inflammation: Uveitis, conjunctivitis (systemic cases)
Organ transplantation: To prevent rejection (in combination)
Certain cancers: As part of chemotherapy regimens (e.g., leukemia)
| Indication | Typical Adult Dose |
|---|---|
| Anti-inflammatory | 560 mg per day depending on severity |
| Acute conditions | High dose tapered over days/weeks |
| Maintenance therapy | Lowest effective dose, often alternate-day use |
ï Always follow physician-directed taperingnever stop suddenly
Use with caution in:
Diabetes (can raise blood glucose)
Hypertension
Peptic ulcer disease
Osteoporosis
Psychiatric disorders
Infections (may mask signs or worsen them)
Long-term use requires monitoring: blood sugar, blood pressure, bone density, eye exams
NSAIDs risk of GI bleeding
Vaccines Avoid live vaccines during treatment
Diuretics risk of electrolyte imbalance
Anti-diabetics May reduce effectiveness
Enzyme inducers/inhibitors (e.g., Rifampicin, Ketoconazole) Affects steroid metabolism
| Short-Term Use | Long-Term Use / High Dose |
|---|---|
| Increased appetite, insomnia | Osteoporosis, adrenal suppression |
| Mood changes, GI upset | Weight gain, Cushingoid appearance |
| Elevated blood sugar | Skin thinning, delayed wound healing |
| Fluid retention, hypertension | Increased infection risk, cataracts |
Tapering is essential after prolonged use to avoid adrenal insufficiency
Store below 25C, in a dry place
Protect from light and moisture
Keep out of reach of children
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