About Polmacoxib Capsules 2mg

Polmacoxib is a selective COX‘2 inhibitor NSAID, with a dual action that includes mild carbonic anhydrase inhibition. Designed to reduce pain and inflammation like conventional NSAIDs”but with a lower gastrointestinal risk profile. elkosgroup.inSteris OnlineWikipedia

Mechanism of Action

COX‘2 Inhibition: Suppresses inflammatory prostaglandins to relieve pain and swelling.
Carbonic Anhydrase Inhibition: Facilitates targeted drug delivery to inflamed joints, minimizing systemic exposure. elkosgroup.inSteris OnlineWikipedia

Indications

Used for managing inflammation and pain in:

Osteoarthritis (hip & knee)
Rheumatoid arthritis
Ankylosing spondylitis
Chronic musculoskeletal pain (e.g. low back, soft tissue)
Postoperative pain
Other inflammatory joint disorders where COX‘2 inhibition is beneficial elkosgroup.inSteris Online

Dosage & Administration

Standard adult dose: 2mg orally once daily, taken with or after meals. Do not exceed 2mg/day. elkosgroup.ininvisionmedi.comSteris Online+1
Take at the same time each day to maintain consistent drug levels. Steris Online+1TrueMeds

Key Benefits

Polmacoxib offers:

Effective, long-lasting pain relief
Better gastrointestinal safety than non-selective NSAIDs
Reduced cardiovascular risk relative to older agents
Supports improved mobility and joint function in chronic cases
Allows once-daily dosing for convenience
Potential synergy with DMARDs or corticosteroids Steris Online

Possible Side Effects

While generally well-tolerated, side effects may include:

Common (mild):

Nausea, heartburn, indigestion, stomach pain, gas, constipation, diarrhea
Headache, dizziness Apollo PharmacySteris Online+1sarthilifesciences.com

Serious/Rare:

Cardiovascular: Risk of heart attack, stroke”especially with long-term use Steris Online+1Synapse
Gastrointestinal: Bleeding, ulcers, perforation (though less common) Apollo PharmacySynapseSteris Online
Renal: Impaired kidney function or acute renal failure Apollo PharmacySteris OnlineSynapse
Liver: Elevated liver enzymes or hepatotoxicity (rare) Steris OnlineSynapse
Allergic: Skin rash, swelling, difficulty breathing”seek immediate help Steris OnlineSynapse

Precautions & Contraindications

Avoid or use with extreme caution in patients with:

History of GI bleeding or ulcers
Cardiovascular disease, uncontrolled hypertension, or heart failure
Kidney or liver impairment
Pregnancy and breastfeeding
Known NSAID or sulfonamide allergies Steris Online+1Apollo Pharmacy

Drug Interactions

Use cautiously with:

Captopril (risk of kidney issues & elevated potassium)
Anticoagulants (e.g., warfarin)”enhanced bleeding risk
ACE inhibitors, ARBs, diuretics”may impair renal function
Methotrexate, lithium”potential toxicity
Co-administration with other NSAIDs or corticosteroids increases GI and renal risks invisionmedi.comSteris Online

Overdose & Missed Dose

Overdose signs: Nausea, vomiting, abdominal pain, drowsiness, dizziness”seek medical help. TrueMeds
Missed dose: Take as soon as remembered unless close to the next dose. Never double up. TrueMeds