Polmacoxib Capsules 2mg

Polmacoxib is a selective COX‘2 inhibitor NSAID, with a dual action that includes mild carbonic anhydrase inhibition. Designed to reduce pain and inflammation like conventional NSAIDs”but with a lower gastrointestinal risk profile. elkosgroup.inSteris OnlineWikipedia

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Mechanism of Action

• COX‘2 Inhibition: Suppresses inflammatory prostaglandins to relieve pain and swelling.

• Carbonic Anhydrase Inhibition: Facilitates targeted drug delivery to inflamed joints, minimizing systemic exposure. elkosgroup.inSteris OnlineWikipedia

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Indications

Used for managing inflammation and pain in:

• Osteoarthritis (hip & knee)

• Rheumatoid arthritis

• Ankylosing spondylitis

• Chronic musculoskeletal pain (e.g. low back, soft tissue)

• Postoperative pain

• Other inflammatory joint disorders where COX‘2 inhibition is beneficial elkosgroup.inSteris Online

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Dosage & Administration

• Standard adult dose: 2mg orally once daily, taken with or after meals. Do not exceed 2mg/day. elkosgroup.ininvisionmedi.comSteris Online+1

• Take at the same time each day to maintain consistent drug levels. Steris Online+1TrueMeds

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Key Benefits

Polmacoxib offers:

• Effective, long-lasting pain relief

• Better gastrointestinal safety than non-selective NSAIDs

• Reduced cardiovascular risk relative to older agents

• Supports improved mobility and joint function in chronic cases

• Allows once-daily dosing for convenience

• Potential synergy with DMARDs or corticosteroids Steris Online

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Possible Side Effects

While generally well-tolerated, side effects may include:

Common (mild):

• Nausea, heartburn, indigestion, stomach pain, gas, constipation, diarrhea

• Headache, dizziness Apollo PharmacySteris Online+1sarthilifesciences.com

Serious/Rare:

• Cardiovascular: Risk of heart attack, stroke”especially with long-term use Steris Online+1Synapse

• Gastrointestinal: Bleeding, ulcers, perforation (though less common) Apollo PharmacySynapseSteris Online

• Renal: Impaired kidney function or acute renal failure Apollo PharmacySteris OnlineSynapse

• Liver: Elevated liver enzymes or hepatotoxicity (rare) Steris OnlineSynapse

• Allergic: Skin rash, swelling, difficulty breathing”seek immediate help Steris OnlineSynapse

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Precautions & Contraindications

Avoid or use with extreme caution in patients with:

• History of GI bleeding or ulcers

• Cardiovascular disease, uncontrolled hypertension, or heart failure

• Kidney or liver impairment

• Pregnancy and breastfeeding

• Known NSAID or sulfonamide allergies Steris Online+1Apollo Pharmacy

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Drug Interactions

Use cautiously with:

• Captopril (risk of kidney issues & elevated potassium)

• Anticoagulants (e.g., warfarin)”enhanced bleeding risk

• ACE inhibitors, ARBs, diuretics”may impair renal function

• Methotrexate, lithium”potential toxicity

• Co-administration with other NSAIDs or corticosteroids increases GI and renal risks invisionmedi.comSteris Online

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Overdose & Missed Dose

• Overdose signs: Nausea, vomiting, abdominal pain, drowsiness, dizziness”seek medical help. TrueMeds

• Missed dose: Take as soon as remembered unless close to the next dose. Never double up. TrueMeds

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Storage

• Store at below 25C, in a cool, dry place, away from sunlight

• Keep sealed and out of children™s reach Apollo Pharmacybsapharmainc.in

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