Amoxycillin & Potassium Clavulanate Oral Suspension IP

Product Description

🊠Amoxycillin & Potassium Clavulanate Oral Suspension IP

This is a broad-spectrum antibiotic suspension used primarily in pediatric patients to treat bacterial infections. The combination enhances antibacterial efficacy, especially against resistant organisms.

🔠Composition & Mechanism:

1. Amoxycillin (as Amoxycillin Trihydrate)

   • Class: Beta-lactam antibiotic (Penicillin group)

   • Action: Inhibits bacterial cell wall synthesis, causing bacterial death.

   • Effective Against: Streptococcus, Staphylococcus (non-MRSA), H. influenzae, E. coli, etc.

2. Potassium Clavulanate (Clavulanic Acid)

   • Class: Beta-lactamase inhibitor

   • Action: Inhibits beta-lactamase enzymes produced by resistant bacteria, allowing Amoxycillin to work effectively.

   • Important Because: Many bacteria are resistant to Amoxycillin alone; clavulanate restores its activity.

… Indications:

Used to treat bacterial infections such as:

• Tonsillitis / Pharyngitis

• Sinusitis

• Otitis media (ear infection)

• Lower respiratory tract infections (bronchitis, pneumonia)

• Urinary tract infections (UTI)

• Skin and soft tissue infections

• Dental infections

š–ï Common Dosage Forms (Suspensions):

Formulated as dry powder for reconstitution (must be mixed with water before use).

Typical strengths (per 5 mL):

• 125 mg Amoxycillin + 31.25 mg Clavulanic acid

• 200 mg + 28.5 mg

• 250 mg + 62.5 mg

• 400 mg + 57 mg (often used in older children)

🉠Dosage (Pediatric Use):

• Based on body weight (usually 20“40 mg/kg/day of Amoxycillin, divided every 8 or 12 hours).

• Exact dose and duration depend on infection severity, child™s weight, and doctor™s judgment.

• Administer after food to improve absorption and reduce GI upset.

šï Precautions & Warnings:

• Complete the full course, even if symptoms improve early.

• Not effective against viral infections (like colds or flu).

• Use caution in patients with penicillin allergy.

• Adjust dose in renal impairment.

• May cause diarrhea or yeast infections due to altered gut flora.

🪠Common Side Effects:

• Diarrhea (often mild, but report persistent cases)

• Nausea, vomiting

• Rash or itching

• Rarely: allergic reactions (anaphylaxis, angioedema)