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A combination medication used to treat neuropathic pain and associated symptoms. It contains:
Pregabalin a GABA analogue that reduces abnormal nerve signaling
Nortriptyline Hydrochloride a tricyclic antidepressant (TCA) that enhances pain modulation and improves mood
This combo works synergistically to relieve chronic nerve pain and improve patient quality of life.
Ingredient | Common Strengths | Function |
---|---|---|
Pregabalin | 75 mg / 150 mg | Reduces nerve signal overactivity and pain |
Nortriptyline HCl | 10 mg / 20 mg | Enhances serotonin & norepinephrine; reduces pain perception |
Strengths may vary by brand or patient condition.
Peripheral Neuropathy (Diabetic, Alcoholic, Chemotherapy-induced)
Postherpetic Neuralgia
Fibromyalgia
Chronic Neuropathic Pain
Lumbar/Cervical Spondylosis with nerve involvement
Mood-related symptoms with chronic pain
Formulation | Typical Dose |
---|---|
Pregabalin 75 mg + Nortriptyline 10 mg | Once or twice daily after meals |
Pregabalin 150 mg + Nortriptyline 1020 mg | Usually once daily at bedtime |
ð Take at a fixed time each day, preferably in the evening if it causes drowsiness.
ð Swallow whole with water; do not chew or crush.
May cause drowsiness, dizziness, or blurred vision
Avoid alcohol it increases sedation and risk of CNS depression
Use cautiously in:
Renal impairment
Cardiac disorders (due to Nortriptyline)
Elderly patients
Pregnancy & breastfeeding only if prescribed
Do not discontinue abruptly risk of withdrawal symptoms
Common | Less Common / Serious |
---|---|
Drowsiness, dizziness | Irregular heartbeat (rare) |
Dry mouth, constipation | Mood changes, confusion |
Increased appetite, weight gain | Suicidal thoughts (rare, with TCAs) |
Blurred vision | Urinary retention (rare) |
Store below 25C, in a dry place
Protect from light and moisture
Keep out of reach of children
Aspect | Details |
---|---|
Form | Oral Tablet |
Use | Neuropathic pain with or without mood symptoms |
Typical Strengths | Pregabalin 75150 mg + Nortriptyline 1020 mg |
Dosage | Once or twice daily (as prescribed) |
Side Effects | Drowsiness, dry mouth, constipation |
Special Caution | Cardiac patients, CNS effects, taper if stopping |
Price: