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Piperacillin & Tazobactam Injection IP

Price 75.0 INR/ Piece

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MOQ : 100 Pieces

Piperacillin & Tazobactam Injection IP Specification

Dosage Form
Powder for Injection

Pacakaging (Quantity Per Box)
1 vial per box

Indication
Severe bacterial infections

Origin of Medicine
Synthetic

Salt Composition
Piperacillin and Tazobactam

Drug Type
Prescription

Ingredients
Piperacillin & Tazobactam

Physical Form
Injection

Function
Antibiotic

Recommended For
Bacterial Infections

Dosage
As prescribed by physician

Dosage Guidelines
Intravenous administration as directed

Suitable For
Adults

Quantity
1 vial

Storage Instructions
Store below 25C, protect from light

Reconstitution
To be reconstituted with sterile water for injection before use

Minimum Order Quantity
100 vials

Strength
4.5 g (Piperacillin 4 g + Tazobactam 0.5 g) per vial

Therapeutic Class
Beta-lactam/Beta-lactamase inhibitor combination

Shelf Life
24 months from manufacturing date

Side Effects
Rash, diarrhea, nausea, allergic reactions, abnormal liver function tests

Prescription Status
Rx Only

Route of Administration
Intravenous (IV) infusion or bolus injection

Marketed By
Leading pharmaceutical companies

Contraindication
Hypersensitivity to penicillins, cephalosporins, or -lactamase inhibitors

Drug Interactions
May interact with anticoagulants, aminoglycosides, and methotrexate

Color
White to off-white powder for reconstitution

Piperacillin & Tazobactam Injection IP Trade Information

Minimum Order Quantity
100 Pieces

Supply Ability
1000 Pieces Per Month

Delivery Time
7 Days

Main Domestic Market
All India

About Piperacillin & Tazobactam Injection IP

Piperacillin & Tazobactam Injection IP

What It Is:

Piperacillin is a broad-spectrum extended-spectrum penicillin antibiotic, and Tazobactam is a -lactamase inhibitor. The combination extends piperacillins effectiveness by protecting it from enzymatic degradation by -lactamase-producing bacteria.

This combination is used to treat serious bacterial infections caused by susceptible organisms, including resistant strains.

Composition:

Each vial contains a fixed-dose combination, commonly:
- Piperacillin Sodium: 4 g
- Tazobactam Sodium: 0.5 g
  (Also available in other ratios like 2g/0.25g or 3g/0.375g depending on product)
Usually supplied as a powder for reconstitution for IV infusion.

Indications:

Effective against a wide range of infections, including:

Complicated intra-abdominal infections
Complicated urinary tract infections (UTIs)
Skin and soft tissue infections
Pneumonia (including hospital-acquired and ventilator-associated)
Sepsis and bacteremia
Gynecological infections
Bone and joint infections

Dosage & Administration:

Adult dose:
- Usually 4.5 g (4 g Piperacillin + 0.5 g Tazobactam) every 6 to 8 hours
- Dosage and frequency may vary with infection severity and renal function
Pediatric dose:
- Dosing based on weight; often 80 mg/kg of Piperacillin component every 68 hours
Route: Intravenous infusion over 30 to 60 minutes (slow infusion)
Reconstitution:
- Reconstitute with sterile water for injection or 0.9% Sodium Chloride solution
- Dilute further in 100 mL or more of IV fluids (NS or Dextrose 5%) for infusion

Precautions & Contraindications:

Contraindications:
- Known hypersensitivity to penicillins, -lactam antibiotics, or tazobactam
Precautions:
- Use cautiously in patients with a history of penicillin allergy
- Adjust dose in renal impairment
- Monitor for signs of superinfection
- Prolonged use may result in Clostridioides difficile-associated diarrhea

Side Effects:

Common	Serious (Rare)
Injection site pain, rash	Anaphylaxis, hypersensitivity
Diarrhea	Seizures (high doses or renal failure)
Nausea, vomiting	Clostridium difficile colitis
Elevated liver enzymes	Stevens-Johnson syndrome

Storage:

Store powder vials at room temperature (1530C)
Protect from moisture
Use freshly reconstituted solution as per guidelines (usually within 24 hours if refrigerated)

Common Brand Names:

Tazocin (Pfizer)
Piptaz
Piptazobactam
Zosyn (international brand name)

Summary Table:

Feature	Details
Drug Class	Penicillin + -lactamase inhibitor
Dose (Adult)	4.5 g IV q68h
Route	IV infusion over 3060 mins
Indications	Serious infections, resistant bacteria
Side Effects	Hypersensitivity, GI upset, rash
Storage	Store powder dry at 1530C

Powerful Dual-Action Antibiotic

Piperacillin & Tazobactam Injection IP offers reliable, broad-spectrum antibacterial activity. By combining Piperacillin, a penicillin-class antibiotic, with Tazobactam, a -lactamase inhibitor, it overcomes resistance mechanisms and is effective against both Gram-positive and Gram-negative bacteria. This makes it an essential therapy for complicated infections, particularly in hospital settings.

Simple Preparation and Administration

The injection comes as a powder that must be reconstituted with sterile water before intravenous use. It can be administered as a slow infusion or as a bolus injection, typically in a hospital or clinical environment under professional supervision. This ensures optimal efficacy and patient safety.

Reliable Storage and Shelf Life

Each vial is packaged to maintain stability and efficacy, with a shelf life of 24 months from the manufacturing date. It should be stored below 25C and protected from light. This stability ensures the product remains effective until its expiration date, supporting inventory management in healthcare settings.

FAQs of Piperacillin & Tazobactam Injection IP:

Q: How is Piperacillin & Tazobactam Injection IP prepared and administered?

A: The injection comes as a white to off-white powder, which must be reconstituted with sterile water for injection before use. Administration is intravenous, given either as an infusion or a bolus injection, always under the supervision of a healthcare professional.

Q: What infections can be treated with this antibiotic combination?

A: Piperacillin & Tazobactam Injection IP is indicated for the treatment of severe bacterial infections, including complicated intra-abdominal, skin, soft tissue, and respiratory tract infections, particularly when bacteria are resistant to other treatments.

Q: When should I avoid using this medication?

A: This antibiotic should not be used if you have a known hypersensitivity to penicillins, cephalosporins, or -lactamase inhibitors. Always inform your healthcare provider of your allergy history before starting treatment.

Q: Where should this medicine be stored to maintain its effectiveness?

A: Store the unreconstituted vials below 25C and protect them from light. Always keep the packaging sealed until ready for use, and use immediately after reconstitution for best results.

Q: What is the process for reconstituting the powder before administration?

A: Add the recommended volume of sterile water for injection to the vial, then gently shake or swirl until the powder dissolves completely to form a clear solution. The solution should be used promptly after preparation to maintain potency.

Q: Are there any common side effects or drug interactions to be aware of?

A: Some individuals may experience rash, diarrhea, nausea, allergic reactions, or abnormal liver function tests. The medication may also interact with anticoagulants, aminoglycosides, and methotrexate; inform your physician about any current medications youre taking.

Q: What is the main benefit of using Piperacillin & Tazobactam Injection IP?

A: This antibiotic offers broad-spectrum bactericidal activity, making it especially effective for treating complex infections where resistance is a concern. Its combination formula helps protect against enzyme-mediated antibiotic degradation, ensuring robust therapeutic action.

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