Piperacillin & Tazobactam Injection IP

Product Description

🉠Piperacillin & Tazobactam Injection IP

🔠What It Is:

Piperacillin is a broad-spectrum extended-spectrum penicillin antibiotic, and Tazobactam is a β-lactamase inhibitor. The combination extends piperacillin™s effectiveness by protecting it from enzymatic degradation by β-lactamase-producing bacteria.

This combination is used to treat serious bacterial infections caused by susceptible organisms, including resistant strains.

🔠Composition:

• Each vial contains a fixed-dose combination, commonly:

  • Piperacillin Sodium: 4 g

  • Tazobactam Sodium: 0.5 g
    (Also available in other ratios like 2g/0.25g or 3g/0.375g depending on product)

• Usually supplied as a powder for reconstitution for IV infusion.

… Indications:

Effective against a wide range of infections, including:

• Complicated intra-abdominal infections

• Complicated urinary tract infections (UTIs)

• Skin and soft tissue infections

• Pneumonia (including hospital-acquired and ventilator-associated)

• Sepsis and bacteremia

• Gynecological infections

• Bone and joint infections

🉠Dosage & Administration:

• Adult dose:

  • Usually 4.5 g (4 g Piperacillin + 0.5 g Tazobactam) every 6 to 8 hours

  • Dosage and frequency may vary with infection severity and renal function

• Pediatric dose:

  • Dosing based on weight; often 80 mg/kg of Piperacillin component every 6“8 hours

• Route: Intravenous infusion over 30 to 60 minutes (slow infusion)

• Reconstitution:

  • Reconstitute with sterile water for injection or 0.9% Sodium Chloride solution

  • Dilute further in 100 mL or more of IV fluids (NS or Dextrose 5%) for infusion

šï Precautions & Contraindications:

• Contraindications:

  • Known hypersensitivity to penicillins, β-lactam antibiotics, or tazobactam

• Precautions:

  • Use cautiously in patients with a history of penicillin allergy

  • Adjust dose in renal impairment

  • Monitor for signs of superinfection

  • Prolonged use may result in Clostridioides difficile-associated diarrhea

🪠Side Effects:

🊠Storage:

• Store powder vials at room temperature (15“30C)

• Protect from moisture

• Use freshly reconstituted solution as per guidelines (usually within 24 hours if refrigerated)

📠Common Brand Names:

• Tazocin (Pfizer)

• Piptaz

• Piptazobactam

• Zosyn (international brand name)

📝 Summary Table: