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Tofacitinib is an oral Janus kinase (JAK) inhibitor used to treat various autoimmune and inflammatory diseases by modulating the immune system response.
Ingredient | Strength |
---|---|
Tofacitinib | 5 mg |
Rheumatoid arthritis (moderate to severe)
Psoriatic arthritis
Ankylosing spondylitis
Ulcerative colitis (moderate to severe)
Other autoimmune disorders as prescribed
Typical dose: 5 mg twice daily or as directed by physician
Can be taken with or without food
Swallow whole with water
Regular monitoring required (blood counts, liver function, lipids) during treatment
Increased risk of infections (including serious infections like tuberculosis)
Avoid live vaccines during treatment
Use cautiously in patients with liver or kidney impairment
Monitor for blood clots (venous thromboembolism)
Not recommended during pregnancy and lactation unless benefits outweigh risks
Common Side Effects | Serious / Rare Side Effects |
---|---|
Headache, dizziness | Serious infections (TB, pneumonia) |
Nasopharyngitis | Blood clots (DVT, PE) |
Increased cholesterol levels | Liver enzyme abnormalities |
Diarrhea | Malignancies (rare) |
Elevated liver enzymes | Gastrointestinal perforations (rare) |
CYP3A4 inhibitors (e.g., ketoconazole) increase tofacitinib levels
CYP3A4 inducers (e.g., rifampin) decrease tofacitinib levels
Avoid live vaccines during treatment
Caution with immunosuppressants
Store at room temperature (below 25C)
Protect from moisture and light
Keep out of reach of children
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