Levofloxacin Tablets IP

Product Description

Levofloxacin Tablets 750 mg is a broad-spectrum antibacterial agent belonging to the fluoroquinolone class. It is the L-isomer of ofloxacin and possesses enhanced potency and a broad range of activity against both gram-positive and gram-negative bacteria.

Levofloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This inhibition disrupts bacterial cell division, resulting in rapid bacterial death.

Each film-coated tablet contains:

• Levofloxacin Hemihydrate IP equivalent to Levofloxacin 750 mg

Pharmacokinetics:

Levofloxacin is rapidly and completely absorbed after oral administration, with peak plasma concentrations typically achieved within 1ï2 hours. The oral bioavailability approaches 99%, making it equivalent to IV administration. It is widely distributed in body tissues and primarily excreted unchanged in urine.

Indications:

Levofloxacin 750 mg is typically reserved for more severe or complicated infections, including:

• Community-acquired pneumonia (CAP), including infections due to Streptococcus pneumoniae

• Complicated urinary tract infections (cUTIs)

• Acute pyelonephritis

• Skin and soft tissue infections

• Acute bacterial sinusitis

• Chronic bacterial prostatitis

• Inhalational anthrax (post-exposure), as per CDC guidelines