Pantoprazole for Injection

About Pantoprazole for Injection

Pantoprazole for Injection

What It Is:

Pantoprazole is a proton pump inhibitor (PPI) used to reduce gastric acid secretion. The injectable form is used when oral administration is not possible, especially in acute care or hospital settings.

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Composition:

• Each vial contains:

  • Pantoprazole Sodium Sesquihydrate equivalent to 40 mg Pantoprazole

• Form: Lyophilized powder for reconstitution

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Indications / Uses:

Used in the treatment of:

• Gastroesophageal reflux disease (GERD) with erosive esophagitis

• Zollinger-Ellison Syndrome and other hypersecretory conditions

• Stress ulcers in critically ill patients

• Peptic ulcer disease

• Prevention of aspiration pneumonia (in surgical/ICU patients)

• Acid suppression before endoscopy for upper GI bleeding

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Dosage & Administration:

To be administered by healthcare professionals only

• Usual Adult Dose:

  • 40 mg once daily via IV injection or IV infusion

Reconstitution Instructions:

1. For IV Injection (Bolus):

   • Reconstitute vial with 10 mL of 0.9% Normal Saline

   • Inject slowly over at least 2 minutes

2. For IV Infusion:

   • Reconstitute and dilute in 100 mL of 0.9% Normal Saline or 5% Dextrose

   • Infuse over 15 minutes

i Do not use other diluents like Ringers or Sodium Bicarbonate

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Duration of Therapy:

• Typically 7 days or until oral therapy can be resumed

• Long-term use may be required in Zollinger-Ellison Syndrome

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i Contraindications:

• Known hypersensitivity to Pantoprazole or other PPIs

• Caution in hepatic impairment

• Not recommended for pediatric use via injection unless prescribed

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a Side Effects:

Common	Rare/Serious
Headache, nausea	Hypomagnesemia
Diarrhea or constipation	Anaphylaxis (rare)
Injection site reaction	Clostridioides difficile infection
Dizziness	Vitamin B12 deficiency (long-term use)

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i Important Notes:

• IV Pantoprazole is bioequivalent to oral formulation, but used only when oral route is not feasible

• Do not mix with other drugs in the same syringe or IV line

• Switch to oral Pantoprazole 40 mg once the patient can tolerate oral intake

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Storage:

• Store vials at 1525C

• Protect from light and moisture

• Use reconstituted solution immediately, or within 4 hours if refrigerated

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How Pantoprazole for Injection Works

Pantoprazole for Injection is a proton pump inhibitor that acts by blocking the final step of gastric acid production in the stomach. This mechanism provides relief from symptoms and promotes healing in acid-related disorders. By reducing stomach acid, the medication helps patients with peptic ulcers, GERD, and stress-related mucosal damage, especially in hospital settings.


Proper Reconstitution and Usage Guidelines

Before intravenous administration, the lyophilized Pantoprazole powder must be reconstituted with 10 mL of 0.9% sodium chloride solution. The reconstituted solution should be used immediately and any unused portion discarded. Only a trained healthcare professional should prepare and administer this medication in a clinical environment, ensuring both safety and accuracy.


Benefits and Indications

Pantoprazole for Injection is recommended for adults with gastric or duodenal ulcers, GERD, Zollinger-Ellison syndrome, or for stress ulcer prevention in critically ill patients. The medication offers rapid and effective acid suppression, aiding recovery while minimizing the risk of further gastrointestinal complications.