Deflazacort Tablets

Deflazacort is a glucocorticoid corticosteroid used to treat inflammatory autoimmune and allergic conditions It is known for having less impact on bone metabolism and glucose tolerance compared to other corticosteroids like prednisolone

Available Strengths

Tablet Strengths Typical Use

6 mg Mild to moderate inflammation

12 mg Moderate to severe conditions

18 mg 30 mg Highdose therapy eg DMD

Uses Indications

Duchenne Muscular Dystrophy DMD a major approved indication

Rheumatoid arthritis lupus polymyositis

Severe allergies skin conditions eczema psoriasis

Nephrotic syndrome

Asthma bronchitis COPD exacerbations

Inflammatory bowel disease Crohns ulcerative colitis

Posttransplant immunosuppression

Autoimmune hematological disorders eg ITP

Dosage Administration

Condition Typical Dose

General inflammation 618 mg once daily

DMD Duchenne 09 mgkgday

Autoimmune conditions Individualized based on response

Always take after food to reduce stomach upset

Morning dose preferred to mimic natural cortisol rhythm

Do not stop suddenly taper gradually as per physicians advice

Precautions

Use with caution in

Diabetes or prediabetes

Hypertension

Osteoporosis

Peptic ulcers

Infections latent or active TB fungal infections

May suppress immune response avoid live vaccines

Longterm use in children may affect growth

Possible Side Effects

Common Serious Longterm

Weight gain increased appetite Osteoporosis cataracts glaucoma

Mood changes insomnia Growth suppression in children

Indigestion bloating Adrenal suppression

Acne fluid retention Increased infection risk

Drug Interactions

Can interact with

Antidiabetic drugs effectiveness

NSAIDs GI bleeding risk

Antifungals anticonvulsants alter metabolism

Vaccines efficacy avoid live vaccines

Storage

Store below 25C

Keep in a dry place away from sunlight

Keep out of reach of children

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