TELMISARTAN & HYDROCHLOROTHIAZIDE TABLETS IP

Product Description

Each tablet typically contains:

• Telmisartan ï an angiotensin II receptor blocker (ARB)

• Hydrochlorothiazide (HCTZ) ï a thiazide diuretic

Common strengths:

• Telmisartan 40 mg + Hydrochlorothiazide 12.5 mg

• Telmisartan 80 mg + Hydrochlorothiazide 12.5 mg

• Telmisartan 80 mg + Hydrochlorothiazide 25 mg

(IP = Indian Pharmacopoeia standard)

ï Uses

• Treatment of essential hypertension

• Used when monotherapy with Telmisartan or HCTZ alone does not adequately control blood pressure

• Reduces risk of stroke, heart failure, and kidney problems associated with hypertension

ïïï Mechanism of Action

• Telmisartan: Blocks angiotensin II receptors ï relaxes blood vessels, reduces blood pressure

• Hydrochlorothiazide: Increases urine output (diuresis) by inhibiting sodium reabsorption in the distal tubules ï reduces blood volume and pressure

ïï Side Effects

Common:

• Dizziness or light-headedness

• Fatigue

• Increased urination

• Electrolyte imbalance (e.g., low potassium, low sodium)

• Muscle cramps

Serious (rare):

• Severe hypotension

• Kidney dysfunction

• High blood uric acid (may worsen gout)

• Allergic reactions

🚫 Contraindications

• Hypersensitivity to Telmisartan, HCTZ, or sulfonamide-derived drugs

• Severe renal or hepatic impairment

• Anuria (inability to produce urine)

• Pregnancy (especially 2nd and 3rd trimesters ï contraindicated)

🔍 Monitoring Parameters

• Blood pressure

• Electrolytes (especially sodium, potassium)

• Renal function (serum creatinine, BUN)

• Blood glucose (HCTZ may increase levels)

• Uric acid (especially in gout patients)

ï Patient Tips

• Take at the same time every day, preferably in the morning (due to diuretic effect)

• Stay hydrated

• Avoid alcohol and excessive salt

• Donït stop medication abruptly

• Use potassium-rich foods only if advised (HCTZ can lower potassium, but Telmisartan can increase it)